Our collaborative research team has received a new four-year NIH Multi-PI R01 to investigate how tobacco smoke-induced metabolic reprogramming and PRMT5 lactylation promote fibroblast activation and pulmonary fibrosis. The project …
Our laboratory has received a four-year renewal of its NIH/NHLBI R01 to investigate how phospho-MARCKS regulates macrophage reprogramming in tobacco smoke-driven pulmonary fibrosis. The project will combine mechanistic studies, genetic …
Abstract Rationale: Cigarette smoking is a major risk factor for lung cancer development and progression; however, the mechanism of how cigarette smoke activates signaling pathways in promoting cancer malignancy remains …
Abstract Argininosuccinate synthase 1 (ASS1) serves as a critical enzyme in arginine biosynthesis; however, its role in interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF), re- mains largely unknown. This …