• Wang HC, Xia R, Chang WH, Hsu SW, Wu CT, Chen CH, Shih TC. Improving cancer immunotherapy in prostate cancer by modulating T cell function through targeting the galectin-1. Front Immunol. 2024 Jun 17;15:1372956. doi: 10.3389/fimmu.2024.1372956. PMID: 38953033; PMCID: PMC11215701.
• Maddali MV, Moore AR, Sinha P, Newton CA, Kim JS, Adegunsoye A, Ma SF, Strek ME, Chen CH, Linderholm AL, Zemans RL, Moore BB, Wolters PJ, Martinez FJ, Rogers AJ, Raj R, Noth I, Oldham JM. Molecular Endotypes of Idiopathic Pulmonary Fibrosis: A Latent Class Analysis of Two Multicenter Observational Cohorts. Am J Respir Crit Care Med. 2024 Jun 24. doi: 10.1164/rccm.202402-0339OC. Epub ahead of print. PMID: 38913573.
• Pugashetti JV, Kim JS, Bose S, Adegunsoye A, Linderholm AL, Chen CH, Strek ME, Flaherty KR, Murray S, Newton CA, Alqalyoobi S, Ma SF, Mychaleckyj JC, Bowler RP, Han MK, Curtis JL, Martinez FJ, Smith JA, Noth I, Oldham JM. Biological Age, Chronological Age and Survival in Pulmonary Fibrosis: A Causal Mediation Analysis. Am J Respir Crit Care Med. 2024 Jun 6. doi: 10.1164/rccm.202310-1887OC. Epub ahead of print. PMID: 38843133.
• Liu J*, Zheng B, Cui Q, Zhu Y, Chu L, Geng Z, Mao Y, Wan L, Cao X, Xiong Q, Guo F, Yang DC, Hsu SW, Chen CH*, Yan X*. Single-Cell Spatial Transcriptomics Unveils Platelet-Fueled Cycling Macrophages for Kidney Fibrosis. Adv Sci (Weinh). 2024 Jun 5:e2308505. doi: 10.1002/advs.202308505. Epub ahead of print. PMID: 38838052.
• Pugashetti JV, Kim JS, Combs MP, Ma SF, Adegunsoye A, Linderholm AL, Strek ME, Chen CH, Dilling DF, Whelan TPM, Flaherty KR, Martinez FJ, Noth I, Oldham JM. A multidimensional classifier to support lung transplant referral in patients with pulmonary fibrosis. J Heart Lung Transplant. 2024 Jul;43(7):1174-1182. doi: 10.1016/j.healun.2024.03.018. Epub 2024 Mar 29. PMID: 38556070.
• Lee CL, Chen KH, Liu WJ, Chen CH, Tsai SF. The association between bone density of lumbar spines and different daily protein intake in different renal function. Ren Fail. 2024 Dec;46(1):2298080. doi: 10.1080/0886022X.2023.2298080. Epub 2024 Jan 8. PMID: 38186360; PMCID: PMC10776072.

• Chu LK, Cao X, Wan L, Diao Q, Zhu Y, Kan Y, Ye LL, Mao YM, Dong XQ, Xiong QW, Fu MC, Zhang T, Zhou HT, Cai SZ, Ma ZR, Hsu SW, Wu R, Chen CH*, Yan XM*, Liu J*. Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury. Nat Commun. 2023 Dec 18;14(1):8393. doi: 10.1038/s41467-023-44228-5. PMID: 38110369; PMCID: PMC10728081. *Corresponding author
• Oldham JM, Huang Y, Bose S, Ma SF, Kim JS, Schwab A, Ting C, Mou K, Lee CT, Adegunsoye A, Ghodrati S, Vu Pugashetti J, Nazemi N, Strek ME, Linderholm AL, Chen CH, Murray S, Zemans RL, Flaherty KR, Martinez FJ, Noth I. Proteomic Biomarkers of Survival in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023 Oct 17. doi: 10.1164/rccm.202301-0117OC. Epub ahead of print. PMID: 37847691.
• Yang DC^#, Hsu SW^#, Li JM, Oldham J, Chen CH. Spatial Decoding of Immune Cell Contribution to Fibroblastic Foci in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023 Jul 24. doi: 10.1164/rccm.202303-0372LE. Epub ahead of print. PMID: 37487177. Featured on the cover of the journal’s Sept. 2023 issue. ^#Equally contributed to this work.

• Li JM, Chang WH, Li L, Yang DC, Hsu SW, Kenyon NJ, Chen CH. Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis. Respir Res. 2023 May 16;24(1):132. doi: 10.1186/s12931-023-02421-6. PMID: 37194070; PMCID: PMC10189934.
• Dong XQ, Chu LK, Cao X, Xiong QW, Mao YM, Chen CH, Bi YL, Liu J, Yan XM. Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis. Redox Rep. 2023 Dec;28(1):2152607. doi: 10.1080/13510002.2022.2152607. PMID: 36692085; PMCID: PMC9879199.
• Lee CL, Liu WJ, Chen CH, Wang JS. Associations of Long-Term Physical Activity Trajectories With All-Cause Mortality in a General Population. Int J Public Health. 2023 Jan 16;68:1605332. doi: 10.3389/ijph.2023.1605332. PMID: 36726527; PMCID: PMC9884672.

• Chang WH^#, Hsu SW^#, Zhang j, Li JM, Yang DC, Chu CH, Yoo EH, Zhang W, Yu SL, Chen CH. MTAP deficiency contributes to immune landscape remodelling and tumour evasion. Immunology. 2022 Oct 1. doi: 10.1111/imm.13587. ^# Equally contributed to this work.

• Chang WH, Chen YJ, Hsiao YJ, Chiang CC, Wang CY, Chang YL, Hong QS, Lin CY, Lin SU, Chang GC, Chen HY, Chen YJ, Chen CH*, Yang PC*, Yu SL*. Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP-deficient lung cancer. EMBO Rep. 2022 08 03; 23(8):e54265. PMID: 35766227; PMCID: PMC9346486. *Corresponding author.
• Chiu CL, Zhao H, Chen CH, Wu R, Brooks JD. The Role of MARCKS in Metastasis and Treatment Resistance of Solid Tumors. Cancers (Basel). 2022 Oct 8;14(19):4925. doi: 10.3390/cancers14194925. PMID: 36230850; PMCID: PMC9563266.

• Liu J, Yang DC, Zhang J, Hsu SW, Weiss RH, Chen CH. A Novel Renoprotective Strategy: Upregulation of PD-L1 Mitigates Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2021; 22(24):13304. https://doi.org/10.3390/ijms222413304.
• Yang DC, Gu S, Li JM, Hsu SW, Chen SJ, Chang WH, Chen CH. Targeting the AXL Receptor in Combating Smoking-related Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2021 Jun;64(6):734-746. doi: 10.1165/rcmb.2020-0303OC. PMID: 33730527.

• Li JM, Yang DC, Oldham J, Linderholm A, Zhang J, Liu J, Kenyon NJ, Chen CH. Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis. Mol Ther. 2021 Apr 7;29(4):1487-1500. doi: 10.1016/j.ymthe.2021.01.028. Epub 2021 Jan 26.PMID: 33508432.

• Liao SY, Linderholm A, Showalter MR, Chen CH, Fiehn O, Kenyon NJ. L-arginine as a potential GLP-1-mediated immunomodulator of Th17-related cytokines in people with obesity and asthma. Obes Sci Pract. 2021 Mar 11;7(3):339-345. doi: 10.1002/osp4.500. eCollection 2021 Jun. PMID: 34123401.
• Liu J, Chen SJ, Hsu SW, Zhang J, Li JM, Yang DC, Gu S, Pinkerton KE, Chen CH. MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer. Theranostics. 2021 Feb 19;11(9):4122-4136. doi: 10.7150/thno.53558. eCollection 2021.PMID: 33754052.

• Li L, Yang DC, Chen CH. Metabolic reprogramming: A driver of cigarette smoke-induced inflammatory lung diseases. Free Radic Biol Med. 2021 Feb 1;163:392-401. doi: 10.1016/j.freeradbiomed.2020.12.438. Epub 2020 Dec 30. Review. PMID: 33387604.

• Yang DC, Chen CH. Potential New Therapeutic Approaches for Renal Cell Carcinoma. Semin Nephrol. 2020 Jan;40(1):86-97. doi: 10.1016/j.semnephrol.2019.12.010. Review. PubMed PMID: 32130970.

• Chen PH, Chen YW, Liu WJ, Hsu SW, Chen CH, Lee CL. Approximate Mortality Risks between Hyperuricemia and Diabetes in the United States. J Clin Med. 2019 Dec 3;8(12). doi: 10.3390/jcm8122127. PubMed PMID: 31816820; PubMed Central PMCID: PMC6947281.
• Yang DC, Li JM, Xu J, Oldham J, Phan SH, Last JA, Wu R, Chen CH. Tackling MARCKS-PIP3 circuit attenuates fibroblast activation and fibrosis progression. FASEB J. 2019 Dec;33(12):14354-14369. doi: 10.1096/fj.201901705R. Epub 2019 Oct 26. PubMed PMID: 31661644; PubMed Central PMCID: PMC6894092.
• Wang CN, Lin YC, Chang BC, Chen CH, Wu R, Lee CC. Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma. Br J Pharmacol. 2019 Apr;176(8):1122-1134. doi: 10.1111/bph.14596. Epub 2019 Mar 27. PubMed PMID: 30706455; PubMed Central PMCID: PMC6451065.
• Xu J, Chang WH, Fong LWR, Weiss RH, Yu SL, Chen CH. Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma. Signal Transduct Target Ther. 2019;4:2. doi: 10.1038/s41392-019-0035-z. eCollection 2019. PubMed PMID: 30701095; PubMed Central PMCID: PMC6345872.

• Yang DC, Chen CH. Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications. J Nat Sci. 2018 Nov;4(11). PubMed PMID: 30801020; PubMed Central PMCID: PMC6383770.
• Silberstein DZ, Karuppanan K, Aung HH, Chen CH, Cross CE, McDonald KA. An oxidation-resistant, recombinant alpha-1 antitrypsin produced in Nicotiana benthamiana. Free Radic Biol Med. 2018 May 20;120:303-310. doi: 10.1016/j.freeradbiomed.2018.03.015. Epub 2018 Mar 16. PubMed PMID: 29551638; PubMed Central PMCID: PMC6093210.

• Fong LWR, Yang DC, Chen CH. Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. Cancer Metastasis Rev. 2017 Dec;36(4):737-747. doi: 10.1007/s10555-017-9709-6. Review. PubMed PMID: 29039083.
• Chang WH, Thai P, Xu J, Yang DC, Wu R, Chen CH. Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction. Int J Mol Sci. 2017 Nov 10;18(11). doi: 10.3390/ijms18112386. PubMed PMID: 29125538; PubMed Central PMCID: PMC5713355.
• Chen CH, Fong LWR, Yu E, Wu R, Trott JF, Weiss RH. Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target. Oncogene. 2017 Jun 22;36(25):3588-3598. doi: 10.1038/onc.2016.510. Epub 2017 Feb 6. PubMed PMID: 28166200; PubMed Central PMCID: PMC5926797.
• Chen CH, Weiss RH. GHetting to know ADPKD proliferative signaling, STAT. Kidney Int. 2017 Mar;91(3):524-526. doi: 10.1016/j.kint.2016.11.024. PubMed PMID: 28202165.

• Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL. HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene. 2016 Oct 27;35(43):5674-5685. doi: 10.1038/onc.2016.106. Epub 2016 Apr 11. PubMed PMID: 27065329.
• Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH. Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. Oncotarget. 2016 Oct 11;7(41):66540-66557. doi: 10.18632/oncotarget.11658. PubMed PMID: 27572319; PubMed Central PMCID: PMC5341819.
• Abu Aboud O, Chen CH, Senapedis W, Baloglu E, Argueta C, Weiss RH. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. Mol Cancer Ther. 2016 Sep;15(9):2119-29. doi: 10.1158/1535-7163.MCT-16-0197. Epub 2016 Jul 7. PubMed PMID: 27390344; PubMed Central PMCID: PMC5010932.

• Chen CH, Cheng CT, Yuan Y, Zhai J, Arif M, Fong LW, Wu R, Ann DK. Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment. Oncotarget. 2015 Jun 20;6(17):15194-208. doi: 10.18632/oncotarget.3827. PubMed PMID: 26015406; PubMed Central PMCID: PMC4558145.
• Tseng YT, Li W, Chen CH, Zhang S, Chen JJ, Zhou X, Liu CC. IIIDB: a database for isoform-isoform interactions and isoform network modules. BMC Genomics. 2015;16 Suppl 2:S10. doi: 10.1186/1471-2164-16-S2-S10. Epub 2015 Jan 21. PubMed PMID: 25707505; PubMed Central PMCID: PMC4331710.
• Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, Wu R. Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1127-38. doi: 10.1164/rccm.201408-1505OC. PubMed PMID: 25318062; PubMed Central PMCID: PMC4299640.
• Chen CC, Chen HY, Su KY, Hong QS, Yan BS, Chen CH, Pan SH, Chang YL, Wang CJ, Hung PF, Yuan S, Chang GC, Chen JJ, Yang PC, Yang YC, Yu SL. Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer. Am J Respir Crit Care Med. 2014 Aug 15;190(4):433-44. doi: 10.1164/rccm.201312-2256OC. PubMed PMID: 25036006.
• Chen CH, Thai P, Yoneda K, Adler KB, Yang PC, Wu R. A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10;33(28):3696-706. doi: 10.1038/onc.2013.336. Epub 2013 Aug 19. PubMed PMID: 23955080; PubMed Central PMCID: PMC4631387.
• Chen CH, Chiu CL, Adler KB, Wu R. A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancer. Am J Respir Crit Care Med. 2014 Apr 15;189(8):1002-4. doi: 10.1164/rccm.201401-0053LE. PubMed PMID: 24735036; PubMed Central PMCID: PMC4098099.
• Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH. Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res. 2013 Oct;92(10):911-7. doi: 10.1177/0022034513499350. Epub 2013 Jul 24. PubMed PMID: 23884556; PubMed Central PMCID: PMC3775371.
• Chuang LY, Chen CH, Shu BC. [Testing the reliability and validity of a parenting scale for Indonesia mothers in transnational marriages]. Hu Li Za Zhi. 2013 Aug;60(4):43-52. doi: 10.6224/JN.60.3.43. PubMed PMID: 23922090.
• Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R. Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol. 2013 Aug;49(2):204-11. doi: 10.1165/rcmb.2013-0159RC. PubMed PMID: 23672216; PubMed Central PMCID: PMC3824039.
• Chen CH, Chuang SM, Yang MF, Liao JW, Yu SL, Chen JJ. A novel function of YWHAZ/β-catenin axis in promoting epithelial-mesenchymal transition and lung cancer metastasis. Mol Cancer Res. 2012 Oct;10(10):1319-31. doi: 10.1158/1541-7786.MCR-12-0189. Epub 2012 Aug 21. PubMed PMID: 22912335.
• Lin YC, Lu MC, Tang HL, Liu HC, Chen CH, Liu KS, Lin C, Chiou CS, Chiang MK, Chen CM, Lai YC. Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbiol. 2011 Mar 8;11:50. doi: 10.1186/1471-2180-11-50. PubMed PMID: 21385400; PubMed Central PMCID: PMC3060850.
• Shu BC, Lung FW, Chen CH. Mental health of female foreign spouses in transnational marriages in southern Taiwan. BMC Psychiatry. 2011 Jan 6;11:4. doi: 10.1186/1471-244X-11-4. PubMed PMID: 21208454; PubMed Central PMCID: PMC3022808.
• Chen CH, Lin H, Chuang SM, Lin SY, Chen JJ. Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells. Exp Cell Res. 2010 Oct 15;316(17):2910-21. doi: 10.1016/j.yexcr.2010.06.027. Epub 2010 Jul 13. PubMed PMID: 20615403.
• Lee CY, Sher HF, Chen HW, Liu CC, Chen CH, Lin CS, Yang PC, Tsay HS, Chen JJ. Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol Cancer Ther. 2008 Nov;7(11):3527-38. doi: 10.1158/1535-7163.MCT-07-2288. PubMed PMID: 19001436.

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• Suppression of allergic lung inflammation and hyperreactivity, U.S. Patent No. 10,314,889, Issued Date: 06/11/2019. Inventors: Wu R, Chen CH, and Lee CC [ISSUED]
• MPS peptides and use thereof, 1) US Patent No. 10189881, Issued Date: 01/29/2019; 2) International Application No. PCT/US2014/048285, Publication No. WO2015013669, Publication Date: 01/29/2015. Inventors: Wu R and Chen CH [ISSUED]
• Method for inhibiting Src kinase activity, R.O.C. Patent No. I418360, Issued Date: 12/11/2013. Inventors: Chen JW, Chen CH, Yu SL and Chang CC [ISSUED]
• MPS modified peptides and use thereof, U.S. Provisional Patent Application No.: 62/849,637, UC case No.: 2019-089, Filed Date: 05/17/2019. Inventors: Chen CH, Wu R, and Yang DC [PENDING]